An integrative systems‐based analysis of substance use: eQTL ‐informed gene‐based tests, gene networks, and biological mechanisms

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The study of expression quantitative trait loci (eQTL) is a powerful way of detecting transcriptional regulators at a genomic scale and for elucidating how natural genetic variation impacts gene expression. Power and genetic resolution are heavily affected by the study population: whereas recombinant inbred (RI) strains yield greater statistical power with low genetic resolution, using diverse ...

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ژورنال

عنوان ژورنال: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

سال: 2020

ISSN: 1552-4841,1552-485X

DOI: 10.1002/ajmg.b.32829